The American Thoracic Society’s 13 assemblies have highlighted these abstracts as some of the most interesting to be presented at the 2011 International Conference in Denver. Starting in mid-April, search for full abstracts by name, title, author or session through “My ATS 2011,” the International Conference’s schedule builder and networking tool. The list below features the name of each abstract and the session during which they will be presented at ATS 2011.
ASSEMBLY ON ALLERGY, IMMUNOLOGY & INFLAMMATION
“Cytokine Profiling in Severe Asthma Subphenotypes Using Factor and Cluster Analysis.” Authors: D. Desai, R.D. May, P. Haldar, S. Shah, S. Gupta, M. Bafadhel, J. Woods, A. Herath, I.K. Anderson, R. Green, A. Wardlaw, P. Bradding, I.D. Pavord, C.E. Brightling; Leicester, Cambridge, United Kingdom. Session: B92 “Phenotypic Fingerprints of (Severe) Asthma.” (Mini-Symposium: Monday, May 16, 2-4:30 p.m., Centennial Ballroom A-B-C, Third Level, Hyatt Regency Denver)
“Identification of the CCL18 Receptor-Effects of CCL18 on Human Lung Fibroblasts in Pulmonary Fibrosis are Mediated via CCR6.” Authors: G. Zissel, K. Höhne, A. Kilic, C. Maier, T. Goldmann, A. Prasse, T. Plönes, M. Trepel, H. Eibel, J. Muller-Quernheim; Freiburg, Borstel, Germany. Session: D14 “Insights into Pathogenesis of Lung Fibrosis and Granulomas.” (Mini-Symposium: Wednesday, May 18, 8:15-10:45 a.m., Centennial Ballroom E (Third Level), Hyatt Regency Denver)
ASSEMBLY ON BEHAVIORAL SCIENCE
“Lower Health Literacy among COPD Patients is Associated with Poorer COPD Functional Outcomes and Greater Risk of COPD-Related Emergency Utilization.” Authors: T.A. Omachi, U. Sarkar, E.H. Yelin, P.D. Blanc, P.P. Katz; San Francisco, CA. Session: A94 “COPD: Factors and Interventions Affecting Adherence and Outcomes.” (Mini-Symposium: Sunday, May 15, 2-4:30 p.m., Korbel Ballroom 1E-1F, Lower Level, Colorado Convention Center)
“Disruption of Maternal Diurnal Cortisol in Pregnancy and Prenatal Body Mass Index (BMI) are Associated with Repeated Wheeze up to Age 2 Years in Urban Children: Project ACCESS.” Authors: R.J. Wright, K. Fisher, Y.-H.M. Chiu, S. Cohen, B. Coull; Boston, MA, Pittsburgh, PA. Session: B101 “Asthma: Psychosocial Factors, Adherence and Quality of Care to Improve Outcomes and Reduce Disparities.” (Poster Discussion Session: Monday, May 16, 2-4:30 p.m., Room 503-504, Street Level, Colorado Convention Center)
ASSEMBLY ON CLINICAL PROBLEMS
“Genome Wide Association Study of Exacerbation Phenotypes in COPD.” Authors: E.S. Wan, M.H. Cho, X. Kong, W. Anderson, R. Tal-Singer, D.A. Lomas, B.J. Klanderman, J. Sylvia, J. Ziniti, P. Bakke, A. Gulsvik, E. Regan, J. Murphy, B.J. Make, J. Crapo, J.E. Hokanson, T.H. Beaty, E.K. Silverman, C.P. Hersh; Boston, MA, King Of Prussia, PA, Research Triangle Park, NC, Cambridge, United Kingdom, Bergen, Norway, Denver, CO, Baltimore, MD. Session: A95 “Cutting Edge Insights to the Pathobiology of COPD and Interstitial Lung Disease.” (Mini-Symposium: Sunday, May 15, 8:15-10:45 a.m., Room 205-207, Street Level, Colorado Convention Center)
“Genetic Variation in Prostaglandin E2 Family Members is Associated with the Development of Primary Graft Dysfunction After Lung Transplantation.” Authors: J.M. Diamond, R. Feng, N.J. Meyer, S.M. Kawut, J.C. Lee, V. Ahya, E. Cantu, L. Ware, S.M. Palmer, S. Bhorade, V. Lama, ?A. Weinacker, J.B. Orens, J. Sonett, K.M. Wille, M. Crespo, D. Weill, B. Kohl, C. Deutschman, S.M. Arcasoy, A. Shah, P. Shah, E.J. Demissie, J. Reynolds, J.A. Belperio, D. Lederer, J.D. Christie; Philadelphia, PA, Nashville, TN, Durham, NC, Chicago, IL, Ann Arbor, MI, Stanford, CT, Baltimore, MD, New York, NY, Birmingham, AL, Pittsburgh, PA, Indianapolis, IN, Los Angeles, CA. Session: C14 “Advances in Lung Transplant Research.” (Mini-Symposium: Tuesday, May 17, 8:15-10:45 a.m., Korbel Ballroom 2A-3A, Lower Level, Colorado Convention Center)
ASSEMBLY ON CRITICAL CARE
“Comparison of Alternative Intensivist Staffing Schedules on Physician and Patient Outcomes in the Intensive Care Unit.” Authors: N.A. Ali, K. Wolf, J. Hammersley, S. Hoffmann, J. O’Brien, G. Phillips, M. Rashkin, T. Warren, A. Garland; Cincinnati, Cleveland, Columbus, Toledo, OH, Indianapolis, IN, Winnipeg, Canada. Session: A15 “Intensive Care Unit Staffing.” (Mini-Symposium: Sunday, May 15, 8:15-10:45 a.m., Korbel Ballroom 1E-1F, Lower Level, Colorado Convention Center)
“Effect of Neuromuscular Blockers on Mortality in Patients with Severe Sepsis.” Authors: J. Steingrub, B.H. Nathanson, T. Lagu, M.B. Rothberg, P.K. Lindenauer Longmeadow; Springfield, MA. Session: B13 “Lung Injury in the Intensive Care Unit: Mechanisms, Therapies, Physiology and Outcomes.” (Mini-Symposium/Monday, May 16, 8:15-10:45 a.m., Korbel Ballroom 4E-4F, Lower Level, Colorado Convention Center)
ASSEMBLY ON ENVIRONMENTAL & OCCUPATIONAL HEALTH
“A Variant in the Vitamin D Receptor Gene (VDR) is Associated with Time to Onset of Chronic Obstructive Pulmonary Disease (COPD) in Men.” Authors: A. Poon, M.H. Cho, D. Sparrow, A.A. Litonjua; Boston, MA. Session: B26 “Dietary Factors, Obesity and Lung Disease.” (Poster Discussion Session: Monday, May 16, 8:15-10:45 a.m., Room 603 (Street Level), Colorado Convention Center)
“Antioxidant Defense and Adult-Onset Incident Asthma: the Shanghai Women’s Asthma and Allergy Study.” Authors: E.K. Larkin, P. Wu, T. Gebretsadik, L.J. Roberts, M. Gross, T. Hartert; Nashville, TN, Minneapolis, MN. Session: B95 “Longitudinal Studies of Asthma.” (Mini-Symposium: Monday, May 16, 8:15-10:45 a.m., Room 605-607, Street Level, Colorado Convention Center)
ASSEMBLY ON MICROBIOLOGY, TUBERCULOSIS & PULMONARY INFECTIONS
“Evaluation of the Xpert MTB/RIF Test for Rapid Detection of Mycobacterium Tuberculosis.” Authors: J.J. Palacios, M.G. Clemente, A. Penedo, H. Jimenez, S. Vázquez, A. Díaz-Escalada, J.M. Garcia, F.J. López, A. Pando, P. Casan; Oviedo, Aviles, Spain. Session: A27 “Diagnosis of Active and Latent Tuberculosis: Novel and Improved Techniques.” (Poster Discussion: Sunday, May 15, 8:15-10:45 a.m., Room 601, Street Level, Colorado Convention Center)
“Novel T Helper Cell Subsets in Immunity to Pseudomonas Aeruginosa Infections.” Authors: H.K. Bayes, T. Evans; Glasgow, United Kingdom. Session: D94 “Bacterial Pneumonia: New Insights into Effective Host Defense.” (Mini-Symposium: Wednesday, May 18, 2-4:30 p.m., Korbel Ballroom 1E-1F, Lower Level, Colorado Convention Center)
ASSEMBLY ON NURSING
“Patient-Clinician Communication about End-of-Life Care Topics.” Authors: L.F. Reinke, C.G. Slatore, J. Uman, E. Udris, B. Moss, R.A. Engelberg, D.H. Au; Seattle, WA, Portland, OR. Session: B59 “End Of Life.” (Thematic Poster Session: Monday, May 16, 8:15 a.m.-4:30 p.m., Area B, Hall B, Upper Level, Colorado Convention Center)
“A Randomized Controlled Trial of an Internet-Based Dyspnea Self-Management Program in Patients with COPD.” Authors: H.Q. Nguyen, D. Donesky-Cuenco, S. Wolpin, J.O. Benditt, S. Paul, V. Carrieri-Kohlman; Seattle, WA, San Francisco, CA. Session: D29 “Dyspnea.” (Poster Discussion Session: Wednesday, May 18, 8:15-10:45 a.m., Room 503-504, Street Level, Colorado Convention Center)
ASSEMBLY ON PEDIATRICS
“LPS-Induced Chorioamnionitis and Antenatal Corticosteroids Modulate Wnt and Shh Signaling in the Fetal Lung.” Authors: J.J.P. Collins, E. Kuypers, G.R. Polglase, I. Nitsos, J.J. Pillow, J.P. Newnham, S.G. Kallapur, A.H. Jobe, B.W. Kramer; Maastricht, Netherlands, Perth, Australia, Cincinnati, OH. Session: B15 “Best of Pediatrics.” (Mini-Symposium: Monday, May 16, 8:15-10:45 a.m., Centennial Ballroom D, Third Level, Hyatt Regency Denver)
“Effect of Adenotonsillectomy on Activity Adjusted Ambulatory Blood Pressure and Left Ventricular Geometry in Children with Obstructive Sleep Apnea.” Authors: L. Burns, R. Vandyke, M. Fenchel, V. Somers, S. Daniels, R.S. Amin; Cincinnati, OH, Rochester, MN, Denver, CO. Session: B15 “Best of Pediatrics.” (Mini-Symposium: Monday, May 16, 8:15-10:45 a.m., Centennial Ballroom D, Third Level, Hyatt Regency Denver)
ASSEMBLY ON PULMONARY CIRCULATION
“Senescence of Microvascular Pulmonary Endothelial Cells Contributes to Sustained Inflammation in Chronic Obstructive Pulmonary Disease (COPD).” Authors: V. Amsellem, V. Chaar, G. Gary-Bobo, H. Noureddine, E. Sapin, B. Maitre, P. Validire, D. Debrosse, S. Le Gouvello, J.-L. Dubois-Rande, J. Boczkowski, S. Adnot; Creteil, Paris, France. Session: A17 “Novel Insights into Pathobiology of Pulmonary Vascular Disease.” (Mini-Symposium: Sunday, May 15, 8:15-10:45 a.m., Room 205-207 (Street Level), Colorado Convention Center)
“Dysregulated microRNA Processing in Pulmonary Arterial Hypertension Contributes to Endothelial and Smooth Muscle Cell Hyperproliferation.” Authors: K.M. Drake, S.A.A. Comhair, S.C. Erzurum, M. Aldred; Cleveland, OH. Session: B16 “Emerging Translational Therapies for Pulmonary Hypertension.” (Mini-Symposium: Monday, May 16, 8:15-10:45 a.m., Centennial Ballroom E, Third Level, Hyatt Regency Denver)
ASSEMBLY ON PULMONARY REHABILITATION
“Vitamin D Supplementation during Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease: An Intervention Study.” Authors: M. Hornikx, A. Lehouck, C. Carremans, C. Mathieu, I. Muylaert, V. Barbier, I. Coosemans, H. Van Remoortel, M. Decramer, T. Troosters, W. Janssens; Leuven, Belgium. Session: B17 “COPD: ?A Disease of the Muscles.” (Mini- Symposium: Monday, May 16, 8:15-10:45 a.m., Room 201-203, Street Level, Colorado Convention Center)
“Regeneration Potential of Muscle Satellite Cells from Patients with Chronic Obstructive Pulmonary Disease.” Authors: M.-E. Theriault, B.B. Lemire, M.-íˆve. Paré, M. A. Caron, R. Debigaré, F. Maltais; Quebec, Canada. Session: B17 “COPD: A Disease of the Muscles.” (Mini- Symposium: Monday, May 16, 8:15-10:45 a.m., Room 201-203, Street Level, Colorado Convention Center)
ASSEMBLY ON RESPIRATORY CELL & MOLECULAR BIOLOGY
“Retinoid-Related Orphan Receptor-Alpha (RORa) and COPD: A New Role for the DNA Damage Response?” Authors: Y. Shi, J. Cao, Y. Zhan, I.O. Rosas, D. Morse; Boston, MA. Session: A18 “Smoke Signals: Illuminating Novel Targets for COPD and Emphysema Intervention.” (Mini-Symposium: Sunday, May 15, 8:15-10:45 a.m., Korbel Ballroom 2A-3A, Lower Level, Colorado Convention Center)
“Toward Cell-Based Therapy for a-Antitrypsin Deficiency through Bi-Allelic Gene Correction in Human iPS Cells.” Authors: S.T. Rashid, K. Yusa, S.J. Marciniak, E. Miranda, A. Ordonez, N. Hannan, G. Alexander, A. Bradley, D.A. Lomas, L. Vallier; Cambridge, United Kingdom, Rome, Italy. Session: A29 “Stem Cells: Who Are You, How Can You Help Me and What Do You Need?” (Poster Discussion Session: Sunday, May 15, 8:15-10:45 a.m., Korbel Ballroom 1A-1B, Lower Level, Colorado Convention Center)
ASSEMBLY ON RESPIRATORY STRUCTURE & FUNCTION
“Bitter Taste Receptor Signaling on Airway Smooth Muscle: ?A Highly Efficacious Pathway for Treating Obstructive Airway Disease.” Authors: K.S. Robinett, D.A. Deshpande, S.B. Liggett; Baltimore, MD. Session: A30 “Novel Mechanisms of Airway Smooth Muscle Contraction and Relaxation: Are These Therapeutically Targetable?” (Poster Discussion Session: Sunday, May 15, 8:15-10:45 a.m., Room 501-502 (Street Level), Colorado Convention Center)
“Roles of the Extracellular Matrix and Physical Stimuli in Lung Regeneration.” Authors: T. Petersen, E. Calle, L. Niklason; Durham, NC, New Haven, CT. Session: B97 “Novel Methods of Information Transfer to and from Stem Cells.” (Mini-Symposium: Monday, May 16, 2-4:30 p.m., Room 102-104-106, Street Level, Colorado Convention Center)
ASSEMBLY ON SLEEP AND RESPIRATORY NEUROBIOLOGY
“Does Continuous Positive Airways Pressure (CPAP) for Minimally Symptomatic Obstructive Sleep Apnoea (OSA) Reduce Daytime Sleepiness? Primary Results from MOSAIC, a Randomized Controlled Trial.” Authors: S.E. Craig, M. Kohler, D. Nicoll, D. Bratton, A. Nunn, R.J.O. Davies, J.R. Stradling; London, Oxford, United Kingdom, Zurich, Switzerland. Session: A19 “Sleep Apnea Treatment Trials.” (Mini-Symposium: Sunday, May 15, 8:15-10:45 p.m., Room 201-203 (Street Level), Colorado Convention Center)
“Intermittent Hypoxia Enhances Cancer Progression in a Mouse Model of Sleep Apnea.” Authors: R. Farre, I. Almendros, J. Montserrat, J. Ramírez, M. Torres, D. Navajas; Barcelona, Spain. Session: C98 “Consequences of Intermittent Hypoxia. (Mini-Symposium: Tuesday, May 17, 2-4:30 p.m., Room 405-406-407 (Street Level), Colorado Convention Center)