American Thoracic Society’s 13 assemblies have highlighted these abstracts as some of the most interesting to be presented at the 2013 International Conference in Philadelphia. The abstracts submitted are reviewed and programmed by the ATS Assembly Program Committees. Each Assembly has chosen two abstracts to showcase as examples of the Assembly’s focus. Starting in April, search for full abstracts by name, title, author, or session online at the ATS 2013 International Conference website.
Assembly on Allergy, Immunology and Inflammation
“Sampling Airway Mucosal Lining Fluid Identifies Roles for IL-33 and Multiple Inflammatory Pathways in Virus-Induced Asthma Exacerbations.” Authors: D.J. Jackson, M.-B. Trujillo-Torralbo, B. Shamji, J. Footitt, J. Del-Rosario, A. Telcian, A. Nikonova, N.W. Bartlett, R.P. Walton, M.R. Edwards, O.-M. Kon, P. Mallia, M. Edwards, J. Westwick, T. Hansel, S.L. Johnston, London, United Kingdom, Horsham, United Kingdom. Session: A13 “Interleukin-33: A Pivotal Mediator for Crosstalk between Innate and Adaptive Inflammatory Responses in the Lung.” (Mini Symposium: 8:15-10:45 a.m., Sunday, May 19, Room 120 A-B-C, Level 100, Pennsylvania Convention Center)
“Characterization of IL-33 and ST2 Expression in Human Asthma.” Authors: E.D. Gordon, M.E. Lachowicz-Scroggins, P.G. Woodruff, J.V. Fahy, San Francisco, CA. Session: A13 “Interleukin-33: A Pivotal Mediator for Crosstalk between Innate and Adaptive Inflammatory Responses in the Lung.” (Mini Symposium: 8:15-10:45 a.m., Sunday, May 19, Room 120 A-B-C, Level 100, Pennsylvania Convention Center)
Behavioral Science and Health Services Research
“Access to Trauma Center Care Following Severe Injury: Are Women at a Disadvantage?” Authors: A. Hill, R. Pinto, A. Nathens, R. Fowler, Toronto, Canada. Session: C94 “Understanding and Overcoming the Effects of Health Disparities on Respiratory Disease Management.” (Mini Symposium: 2-4:30 p.m., Tuesday, May 21, Grand Ballroom E, Level 5, Philadelphia Marriott Downtown)
“Clinical Impacts of Reimbursement Changes for Fixed ICS/LABA Combination Therapy in Well-Controlled Asthma and COPD Patients in Iceland.” Authors: U.S. Björnsdottir, S. Sigurdardottir, J.S. Jonsson, I. Naya, M. Jonsson, G. Telg, M. Thuresson, S. Gizurarson Reykjavik, Iceland, Alderley Park, United Kingdom, Södertälje, Sweden, Uppsala, Sweden. Session: D15 “Factors Affecting Patient Adherence to Respiratory Disease Treatments.” (Mini Symposium: 8:15-10:45 a.m., Wednesday, May 22, Room 204 A-B, Level 200, Pennsylvania Convention Center)
Assembly on Clinical Problems
“Defective Toll like Receptor 3 (TLR3) Activation Promotes Dysregulated Fibroproliferation in the Lung and a Rapidly Progressive Clinical Phenotype in Idiopathic Pulmonary Fibrosis (IPF).” Authors: D.N. O’Dwyer, M.E. Armstrong, N. Hirani, M.P. Keane, M. Whyte, P.G. Fallon, G. Trujillo, C.M. Hogaboam, S. Donnelly, Dublin, Ireland, Edinburgh, Sheffield, United Kingdom, Ann Arbor, MI. Session: A22 “Interstitial Lung Disease: Evaluation and Pathobiology.” (Poster Discussion Session: 8:15-10:45 a.m., Sunday, May 19, Room 201 C, Level 200, Pennsylvania Convention Center)
“Persistence over Time of Elevated Levels of Circulating Apoptotic Endothelial Microparticles in COPD Despite Smoking Cessation.” Authors: A. Krause, C. Gordon, Y. Strulovici-Barel, M.R. Staudt, J. Fuller, A.E. Tilley, B.-G. Harvey, R.J. Kaner, J. Yee-Levin, S. Radisch, C. Hollmann, N.R. Hackett, N. Tignor, J.G. Mezey, H. Bitter, S. Sridhar, S. Pillai, H. Hilton, G. Wolff, S. Visvanathan, J.S. Fine, C.S. Stevenson, R.G. Crystal, New York, NY, Nutley, NJ. Session: B22 “Chronic Obstructive Pulmonary Disease: Understanding the Lung and Heart Interaction.” (Poster Discussion Session: 8:15-10:45 a.m., Monday, May 20, Room 203 A-B, Level 200, Pennsylvania Convention Center)
Assembly on Critical Care
“Plasma Angiopoietin-2 Predicts the Onset of Acute Lung Injury in Critically Ill Patients.” Authors: A. Agrawal, M.A. Matthay, K.N. Kangelaris, J. Stein, J.C. Chu, B.M. Imp, A. Cortez, J. Abbott, K. Liu, C.S. Calfee, San Francisco, CA. Session: A105 “Acute Respiratory Distress Syndrome: Risk Factors, Biomarkers, and a New Definition.” (Poster Discussion Session: 2-4:30 p.m., Sunday, May 19, Room 202 A-B, Level 200, Pennsylvania Convention Center)
“Metabolomic Analysis in Sepsis and ARDS.” Authors: A.M. Esper, Y. Park, G.S. Martin, D. Jones, Atlanta, GA. Session: A105 “Acute Respiratory Distress Syndrome: Risk Factors, Biomarkers, and a New Definition.” (Poster Discussion Session: 2-4:30 p.m., Room 202 A-B Level 200, Pennsylvania Convention Center)
Assembly on Environmental and Occupational Health
“Searching for the Culprit: Is Urban Particulate Air Pollution or Road Traffic Noise Responsible for the Association of Traffic Proximity with Subclinical Atherosclerosis—Results from the Heinz Nixdorf Recall Study.” Authors: B. Hoffmann, F. Hennig, S. Moebus, S. Mohlenkamp, N. Dragano, H. Jakobs, R. Erbel, K.-H. Jockel, H. Kalsch, Dusseldorf, Essen, Cologne, Germany. Session: B95 “Air Pollution: From Bench to Roadside.” (Mini Symposium: 2-4:30 p.m., Monday, May 20, Grand Ballroom E, Level 5, Philadelphia Marriott Downtown)
“Chronic Obstructive Pulmonary Disease in People Exposed to Wood Smoke. PREPOCOL: A Population Based Study.” Authors: C.A. Torres-Duque, A. Caballero, M. Gonzalez-Garcia, C. Jaramillo, D. Maldonado, Bogota, Colombia. Session: B105 “Chronic Obstructive Pulmonary Disease Classification and Course.” (Poster Discussion Session: 2-4:30 p.m., Monday, May 20, Grand Ballroom A-B, Level 5, Philadelphia Marriott Downtown)
Assembly on Microbiology, Tuberculosis and Pulmonary Infections
“Blood Gene Expression Profiling Reveals an Association between Viral Infection, Platelet Function, and Acute Myocardial Infarction.” Authors: J.J. Rose, D. Voora, D.D. Cyr, J.E. Lucas, A.K. Zaas, L.K. Newby, W.E. Kraus, G.S. Ginsburg, Durham, NC. Session: A 25 “The Changing Face of Pneumonia and its Management.” (Poster Discussion Session: 8:15-10:45 a.m., Sunday, May 19, Room 113 A, Level 100, Pennsylvania Convention Center)
“My-D88 Adapter Like (Mal) is Required for Effective Macrophage Responses to Mycobacterium Tuberculosis.” Authors: C. Ni Cheallaigh, J. Harris, S. Gordon, L. O’Neill, E. Lavelle, J. Keane, Dublin, Ireland. Session: A16 “Tuberculosis: Host Defense.”(Mini Symposium: 8:15-10:45 a.m., Sunday, May 19, Room 119 A-B, Level 100), Pennsylvania Convention Center)
Assembly on Nursing
“Factors Associated with Asthma Control in High Risk Children.” Authors: A. Butz, M. Bellin, K. Frick, J. Kub, C. Lewis-Land, M.E. Bollinger, Baltimore, MD. Session: C96 “Innovations In Pulmonary, Critical Care, and Sleep.” (Mini Symposium: 2-4:30 p.m., Tuesday, May 21, Room 107 A-B, Level 100, Pennsylvania Convention Center)
“Low Dose CT Lung Cancer Screening Experience at a VA Medical Center.” Authors: S.H. Yoon, R. Goldstein, A. Jati, W. Arndt, Boston, MA. Session: C96 “Innovations In Pulmonary, Critical Care, and Sleep.” (Mini Symposium: 2-4:30 p.m., Tuesday, May 21, Room 107 A-B, Level 100, Pennsylvania Convention Center)
Assembly on Pediatrics
“Thromboxane A2 Receptor Associated with Near Fatal Exacerbations in Children with Asthma.” Authors: C.L. Carroll, K.A. Sala, C.M. Schramm, A.R. Zucker. Hartford, CT. Session: B28 “Modulators of Asthma Severity.” (Poster Discussion Session: 8:15-10:45 a.m., Monday, May 20, Room 108 A-B, Level 100, Pennsylvania Convention Center)
“Cluster Analysis of Asthma Phenotypes in Children Ages 6 to 18 Years from the EVE Consortium.” Authors: W.A. Gower, X. Li, H. Li, E.J. Ampleford, E.R. Bleecker, D.A. Meyers, Winston-Salem, NC. Session: C17 “Best of Pediatrics.” (Mini Symposium: 8:15-10:45 a.m., Tuesday, May 21, Room 120 A-B-C, Level 100, Pennsylvania Convention Center)
Assembly on Pulmonary Circulation
“Targeted Pulmonary Delivery of a microRNA-145 Inhibitor Reverses Severe Pulmonary Arterial Hypertension in Rats.” Authors: J.M. McLendon, S.R. Joshi, M. Matar, J.G. Fewell, M. Oka, I. McMurtry, W.T. Gerthoffer, Mobile, Huntsville, AL. Session: A97 “The Role of MicroRNAs in Pulmonary Vascular Disease.” (Mini Symposium: 2-4:30 p.m., Sunday, May 19, Grand Ballroom F, Level 5, Philadelphia Marriott Downtown)
“Intersectin-1s Deficiency and the Altered Endocytic Trafficking and Smad2/3 Signaling of TGFß/Alk5 Contribute to Abnormal Lung Endothelial Cell Proliferation.” Authors: C. Bardita, D.N. Predescu, S.A. Predescu, Chicago, IL. Session: C97 “Molecular Mechanisms of Endothelial Barrier Function.” (Mini Symposium: 2-4:30 p.m., Tuesday, May 21, Lecture Hall Space 114, Level 100, Pennsylvania Convention Center)
Assembly on Pulmonary Rehabilitation
“Directly-Measured Physical Activity Predicts Subsequent Hospitalization in Patients with Chronic Obstructive Pulmonary Disease.” Authors: S. Zanoria, R. ZuWallack, Farmington, Hartford, CT. Session: C18 “Pulmonary Rehabilitation Highlights.”(Mini Symposium: 8:15-10:45 a.m., Tuesday, May 21, Grand Ballroom 6, Level 5, Philadelphia Marriott Downtown)
“Impact of Outpatient Pulmonary Rehabilitation on Arterial Stiffness in Patients with Chronic Obstructive Pulmonary Disease.” Authors: M.K. Stickland, L.E. Moore, H. Edgell, D.P. Fuhr, M. Bhutani, E.Y.L. Wong, W.J. McGarvey, Edmonton, Canada. Session: C107 “Pulmonary Rehabilitation: Organization and Outcomes.” (Poster Discussion Session: 2-4:30 p.m., Tuesday, May 21, Room 203 A-B, Level 200, Pennsylvania Convention Center)
Assembly on Respiratory Cell And Molecular Biology
“Smoking Dysregulated Genes in Human Airway Basal Cells Localize to Specific Chromosomal ‘Hot Spots.'” Authors: D.M. Ryan, J. Salit, M.S. Walters, N.R. Hackett, T.L. Vincent, J.G. Mezey, R.G. Crystal, New York, NY. Session: C19 “Mucin Gene Regulation and Function: How Muc(H) Have We Learned?” (Mini Symposium: 8:15-10:45 a.m., Tuesday, May 21, Room 204 A-B, Level 200, Pennsylvania Convention Center)
“Autocrine Regulation of Fibrotic Differentiation and ß-Catenin Stabilization in Human Adult Lung Mesenchymal Stromal Cells By LPA Autotaxin Axis.” Authors: V.N. Lama, N. Walker, L. Badri, Ann Arbor, MI. Session: C21 “It Takes a Village to Repair the Lung: Cells, Pathways, and Methods.”(Poster Discussion Session: 8:15-10:45 a.m., Tuesday, May 21, Room 202 A-B, Level 200, Pennsylvania Convention Center)
Assembly on Respiratory Structure And Function
“Soluble ADAM33 Determines Mechanical Behaviors of Airway Smooth Muscle Cells.” Authors: L. Deng, J. Long, Y. Duan, J. Chen, F. Lin, R. Xu, X. Jiang. Changzhou, Chongqing, China. Session: A108 “Airway Smooth Muscle: New Ways to Relax and Behave.” (Poster Discussion Session: 2-4:30 p.m., Sunday, May 19, Room 201 C, Level 200, Pennsylvania Convention Center)
“The Localization of Bronchiolitis Obliterans in Rejected Lung Allografts Using a Combination of MDCT, MicroCT, and Histology.” Authors: S. Verleden, D.M. Vasilescu, S. Willems, D. Ruttens, R. Vos, E. Vandermeulen, J.E. McDonough, E.K. Verbeken, J.A. Verschakelen, D.E. Van Raemdonck, B. Rondelet, C. Knoop, J.D. Cooper, M. Decramer, J.C. Hogg, G. Verleden, B. Vanaudenaerde, Leuven, Brussels, Belgium, Vancouver, Canada, Philadelphia, PA. Session: D29 “Use of Emerging Imaging Techniques as Biomarkers of Lung Disease.” (Poster Discussion Session: 8:15-10:45 a.m., Wednesday, May 22, Room 202 A-B, Level 200, Pennsylvania Convention Center)
Assembly on Sleep And Respiratory Neurobiology
“Chronic Sleep Disruption (SD) Induces Accelerated TC1 Cell Tumor Growth and Invasiveness Via Recruitment of Tumor-Associated Macrophages (TAM) in Mice.” Authors: F. Hakim, Y. Wang, S.X.L. Zhang, E.S. Yolcu, A. Carreras, H. Shirwan, D. Gozal. Chicago, IL, Louisville, KY. Session: A109 “Sleep Disordered Breathing: Cardiovascular, Metabolic and Neurocognitive Outcomes.” (Poster Discussion Session: Sunday, May 19, 2-4:30 p.m., Grand Ballroom C-D, Level 5, Philadelphia Downtown Marriott)
“Effective Treatment of Obstructive Sleep Apnea Improves Glucose Tolerance in Prediabetes: A Randomized Placebo-Controlled Study.” Authors: S. Pamidi, M. Stepien, K. Sharif-Sidi, H. Whitmore, L. Morselli, K. Wroblewski, E. Tasal, Montreal, Canada, Chicago, IL Session: B19 “Sleep Disordered Breathing and Metabolism: Mechanisms, Confounders and Outcomes.”(Mini Symposium: 8:15-10:45 a.m., Monday, May 20, Room 204 A-B, Level 200, Pennsylvania Convention Center)